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Each of these peptides has a distinct mechanism of action, therapeutic niche and side-profile that can be understood by looking at their pharmacology, approved uses and practical experience.
Tesamorelin vs Sermone: Which Peptide Fuels Fat Loss and Recovery?
Both tesamorelin and sermone are synthetic analogues of growth hormone releasing hormone (GHRH).
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Because of its higher affinity for the receptor and longer duration of action, tesamorelin is more effective at stimulating endogenous growth hormone release than sermone.
This translates into a greater reduction of visceral adipose tissue when used chronically.
In patients with HIV-associated lipodystrophy, daily subcutaneous
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is not seen with sermone at the same dose.
Sermone, on the other hand, has a shorter half-life
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Tesamorelin (brand name Egrifta) was approved by the Food and Drug Administration in 2010
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subcutaneous injection once daily. The drug stimulates growth hormone release, which in turn increases lipolysis in visceral adipocytes and enhances insulin sensitivity.
Sermone (brand name Serostim) has been on the market for many
years as a therapy for growth hormone deficiency in adults and children. It is also used off-label for weight loss,
muscle wasting or as an adjunct to other anabolic therapies.
Sermone is given at doses ranging from 1 mg to 3 mg per day subcutaneously, usually divided into
two injections.
How Tesamorelin Works
Tesamorelin mimics the natural peptide GHRH by binding to its receptor on pituitary somatotrophs.
This activation triggers a cascade of intracellular events that culminate in the synthesis and
release of growth hormone into the bloodstream. Once released, growth hormone travels to peripheral tissues
where it binds to the growth hormone receptor and activates signaling pathways
that promote lipolysis, protein synthesis and cell proliferation.
In visceral fat cells, growth hormone increases the activity of
hormone-sensitive lipase, which breaks down triglycerides into free fatty
acids that are then released into circulation. The rise in circulating free fatty acids provides a fuel source
for oxidative metabolism and reduces the storage of excess
calories as adipose tissue. In addition, growth hormone improves insulin sensitivity by
reducing hepatic glucose production and increasing peripheral uptake of glucose.
Because tesamorelin’s effect is mediated through the body’s own endocrine system, it avoids many
of the adverse effects associated with direct administration of exogenous growth hormone,
such as fluid retention or arthralgia. However, because it still increases endogenous growth hormone levels, it can cause transient increases in blood sugar and may need to be monitored in patients with
diabetes.
In clinical practice, tesamorelin is typically started at 1 week before and after dianabol mg per day and titrated up to 2
mg once daily after an initial assessment of tolerance.
The drug should be used for a minimum of 12 weeks before evaluating changes in visceral fat
by imaging or anthropometric measurements. If no significant improvement is seen after 48 weeks,
discontinuation may be considered.
Conclusion
While all three peptides stimulate growth hormone release, tesamorelin stands out as the most potent agent for targeted reduction of abdominal adiposity and for improving metabolic parameters in HIV-associated lipodystrophy.
Sermone remains a useful tool for treating growth hormone deficiency and supporting
muscle recovery but is less effective for fat loss when used alone.
Ipamorelin, not discussed in detail here, offers a different profile with a more selective action on the
ghrelin receptor that can promote appetite and lean mass while
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The comparison of ipamorelin, tesamorelin and sermorelin is often asked by people who are interested in peptide therapy for body
composition, anti-aging or clinical conditions such as HIV-associated lipodystrophy.
Each of these peptides has a distinct mechanism of action, therapeutic niche and side-profile that can be understood by looking at their pharmacology, approved uses and practical experience.
Tesamorelin vs Sermone: Which Peptide Fuels Fat Loss and Recovery?
Both tesamorelin and sermone are synthetic analogues of growth hormone releasing hormone (GHRH).
They bind to the GHRH receptor on pituitary cells but they differ
in their potency, half-life and downstream effects.
Because of its higher affinity for the receptor and longer duration of action, tesamorelin is more effective at stimulating endogenous growth hormone release than sermone.
This translates into a greater reduction of visceral adipose tissue when used chronically.
In patients with HIV-associated lipodystrophy, daily subcutaneous
injections of 2 mg tesamorelin for up to 48 weeks have produced a mean decrease in abdominal fat volume of about 20 percent and an improvement in insulin sensitivity that
is not seen with sermone at the same dose.
Sermone, on the other hand, has a shorter half-life
and elicits a smaller peak in growth hormone secretion. It is therefore less effective
as a stand-alone agent for fat loss but it can be used safely to stimulate muscle anabolism or support recovery after
surgery when combined with anabolic steroids or protein supplementation.
Overview of Tesamorelin and Sermone
Tesamorelin (brand name Egrifta) was approved by the Food and Drug Administration in 2010
specifically for reduction of excess abdominal fat in adults with HIV infection who have a high visceral
adipose tissue volume. It is administered as a 2 mg
subcutaneous injection once daily. The drug stimulates growth hormone release, which in turn increases lipolysis in visceral adipocytes and enhances insulin sensitivity.
Sermone (brand name Serostim) has been on the market for many
years as a therapy for growth hormone deficiency in adults and children. It is also used off-label for weight loss,
muscle wasting or as an adjunct to other anabolic therapies.
Sermone is given at doses ranging from 1 mg to 3 mg per day subcutaneously, usually divided into
two injections.
How Tesamorelin Works
Tesamorelin mimics the natural peptide GHRH by binding to its receptor on pituitary somatotrophs.
This activation triggers a cascade of intracellular events that culminate in the synthesis and
release of growth hormone into the bloodstream. Once released, growth hormone travels to peripheral tissues
where it binds to the growth hormone receptor and activates signaling pathways
that promote lipolysis, protein synthesis and cell proliferation.
In visceral fat cells, growth hormone increases the activity of
hormone-sensitive lipase, which breaks down triglycerides into free fatty
acids that are then released into circulation. The rise in circulating free fatty acids provides a fuel source
for oxidative metabolism and reduces the storage of excess
calories as adipose tissue. In addition, growth hormone improves insulin sensitivity by
reducing hepatic glucose production and increasing peripheral uptake of glucose.
Because tesamorelin’s effect is mediated through the body’s own endocrine system, it avoids many
of the adverse effects associated with direct administration of exogenous growth hormone,
such as fluid retention or arthralgia. However, because it still increases endogenous growth hormone levels, it can cause transient increases in blood sugar and may need to be monitored in patients with
diabetes.
In clinical practice, tesamorelin is typically started at 1 week before and after dianabol mg per day and titrated up to 2
mg once daily after an initial assessment of tolerance.
The drug should be used for a minimum of 12 weeks before evaluating changes in visceral fat
by imaging or anthropometric measurements. If no significant improvement is seen after 48 weeks,
discontinuation may be considered.
Conclusion
While all three peptides stimulate growth hormone release, tesamorelin stands out as the most potent agent for targeted reduction of abdominal adiposity and for improving metabolic parameters in HIV-associated lipodystrophy.
Sermone remains a useful tool for treating growth hormone deficiency and supporting
muscle recovery but is less effective for fat loss when used alone.
Ipamorelin, not discussed in detail here, offers a different profile with a more selective action on the
ghrelin receptor that can promote appetite and lean mass while
sparing visceral fat. Each peptide should
be chosen based on the patient’s specific clinical goal, comorbidities and tolerance to hormone therapy.
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